The most popular antidepressants are selective serotonin reuptake inhibitors, or SSRIs. This group includes some of the most popular prescription drugs on the planet such as Zoloft, Prozac, Celexa, Lexapro, and Paxil. Common Prozac alternatives include other depression medications or different kinds of therapy. This eMedTV segment describes these various options in detail, including an extensive list of other antidepressants that can be used with links to learn more. 2 Natural Antidepressants Found to Be as Effective as Prozac Studies show that some natural antidepressants can have equal effects to the prescription drug fluoxetine (generic form of Prozac) without the adverse effects. At the time this article was written, a 30-day supply of Prozac was about $100 more than a similar supply of Zoloft. To check the most current pricing, though, you can visit GoodRx.com. As you can read based on the chart below, Prozac and Zoloft are similar in some ways and different in others. Prozac contains fluoxetine, whereas Zoloft contains sertraline. Prozac contains fluoxetine, whereas Zoloft contains sertraline. Prozac is sometimes used together with another medication called olanzapine (Zyprexa) to treat manic depression caused by bipolar disorder. This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms. How to use Prozac. Read the Medication Guide provided by your pharmacist before you start using fluoxetine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Individuals seeking alternatives to Prozac for anxiety or depression may find that their doctor wants to keep them on medication and if this drug isn’t working; the doctor may suggest another similar drug. Doctors often prescribe the following prescription medications as Fluoxetine alternatives: other selective serotonin reuptake inhibitors (SSRIs) such as Paxil (Paroxetine), selective. Fluoxetine is sometimes used together with another medication called olanzapine (Zyprexa) to treat manic depression caused by bipolar disorder. This combination is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms. Defines the medication fluoxetine (Prozac, Sarafem, Prozac Weekly) a drug used in the treatment of depression, obsessive-compulsive disorders, panic attacks, and premenstrual dysphoric disorder. Article includes descriptions, uses, drug interactions, and side effects.